Stochastic modeling, virtual refinement and deterministic fabrication of tissue engineering scaffolds

Richard A. Robb, Srinivasan Rajagopalan

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Tissue engineering attempts to address the ever widening gap between the demand and supply of organ and tissue transplants using natural and biomimetic scaffolds. The current scaffold fabrication techniques can be broadly classified into (a) conventional, irreproducible, stochastic techniques producing biomorphic "secundam naturam" but sub optimal scaffold architecture and (b) rapidly emerging, repeatable, computer-controlled Solid Freeform Fabrication (SFF) producing, "contra naturam" scaffold architecture. This paper presents an image-based scaffold optimization strategy based on microCT images of the conventional scaffolds. This approach, attempted and perfected for the first time, synergistically exploits the orthogonal techniques to create repeatable, biomorphic scaffolds with optimal scaffold geometry. The ramifications of this image based computer assisted intervention to improve the status quo of scaffold fabrication might contribute to the previously elusive deployment of promising benchside tissue analogs to the clinical bedside.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2006
Subtitle of host publicationVisualization, Image-Guided Procedures, and Display
StatePublished - 2006
EventMedical Imaging 2006: Visualization, Image-Guided Procedures, and Display - San Diego, CA, United States
Duration: Feb 12 2006Feb 14 2006

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2006: Visualization, Image-Guided Procedures, and Display
Country/TerritoryUnited States
CitySan Diego, CA


  • Image-based metrology
  • MicroCT
  • MicroMR
  • Porous scaffolds
  • Random media
  • Tissue engineering
  • Virtual refinement

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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