Stiffness and beyond: What MR elastography can tell us about brain structure and function under physiologic and pathologic conditions

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Brain magnetic resonance elastography (MRE) was developed on the basis of a desire to "palpate by imaging" and is becoming a powerful tool in the investigation of neurophysiological and neuropathological states. Measurements are acquired with a specialized MR phase-contrast pulse sequence that can detect tissue motion in response to an applied external or internal excitation. The tissue viscoelasticity is then reconstructed from the measured displacement. Quantitative characterization of brain viscoelastic behaviors provides us an insight into the brain structure and function by assessing the mechanical rigidity, viscosity, friction, and connectivity of brain tissues. Changes in these features are associated with inflammation, demyelination, and neurodegeneration that contribute to brain disease onset and progression. Here, we review the basic principles and limitations of brain MRE and summarize its current neuroanatomical studies and clinical applications to the most common neurosurgical and neurodegenerative disorders, including intracranial tumors, dementia, multiple sclerosis, amyotrophic lateral sclerosis, and traumatic brain injury. Going forward, further improvement in acquisition techniques, stable inverse reconstruction algorithms, and advanced numerical, physical, and preclinical validation models is needed to increase the utility of brain MRE in both research and clinical applications.

Original languageEnglish (US)
Pages (from-to)305-318
Number of pages14
JournalTopics in Magnetic Resonance Imaging
Issue number5
StatePublished - 2018


  • brain
  • dementia
  • intracranial tumors
  • magnetic resonance elastography
  • multiple sclerosis
  • neurodegenerative diseases
  • slip interface imaging
  • stiffness
  • viscoelasticity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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