TY - GEN
T1 - Standardized drug and pharmacological class network construction
AU - Zhu, Qian
AU - Jiang, Guoqian
AU - Wang, Liwei
AU - Chute, Christopher G.
PY - 2013
Y1 - 2013
N2 - Dozens of drug terminologies and resources capture the drug and/or drug class information, ranging from their coverage and adequacy of representation. No transformative ways are available to link them together in a standard way, which hinders data integration and data representation for drug-related clinical and translational studies. In this paper, we introduce our preliminary work for building a standardized drug and drug class network that integrates multiple drug terminological resources, using Anatomical Therapeutic Chemical (ATC) and National Drug File Reference Terminology (NDF-RT) as network backbone, and expanding with RxNorm and Structured Product Label (SPL). The network consists of 39,728 drugs and drug classes. We calculated and compared structure similarity for each drug/drug class pair from ATC and NDF-RT, and analyzed constructed drug class network from chemical structure perspective.
AB - Dozens of drug terminologies and resources capture the drug and/or drug class information, ranging from their coverage and adequacy of representation. No transformative ways are available to link them together in a standard way, which hinders data integration and data representation for drug-related clinical and translational studies. In this paper, we introduce our preliminary work for building a standardized drug and drug class network that integrates multiple drug terminological resources, using Anatomical Therapeutic Chemical (ATC) and National Drug File Reference Terminology (NDF-RT) as network backbone, and expanding with RxNorm and Structured Product Label (SPL). The network consists of 39,728 drugs and drug classes. We calculated and compared structure similarity for each drug/drug class pair from ATC and NDF-RT, and analyzed constructed drug class network from chemical structure perspective.
UR - http://www.scopus.com/inward/record.url?scp=84894309734&partnerID=8YFLogxK
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U2 - 10.3233/978-1-61499-289-9-1125
DO - 10.3233/978-1-61499-289-9-1125
M3 - Conference contribution
C2 - 23920899
AN - SCOPUS:84894309734
SN - 9781614992882
T3 - Studies in Health Technology and Informatics
SP - 1125
BT - MEDINFO 2013 - Proceedings of the 14th World Congress on Medical and Health Informatics
PB - IOS Press
T2 - 14th World Congress on Medical and Health Informatics, MEDINFO 2013
Y2 - 20 August 2013 through 23 August 2013
ER -