TY - JOUR
T1 - Standardized brain tumor imaging protocols for clinical trials
T2 - current recommendations and tips for integration
AU - Sanvito, Francesco
AU - Kaufmann, Timothy J.
AU - Cloughesy, Timothy F.
AU - Wen, Patrick Y.
AU - Ellingson, Benjamin M.
N1 - Publisher Copyright:
2023 Sanvito, Kaufmann, Cloughesy, Wen and Ellingson.
PY - 2023
Y1 - 2023
N2 - Standardized MRI acquisition protocols are crucial for reducing the measurement and interpretation variability associated with response assessment in brain tumor clinical trials. The main challenge is that standardized protocols should ensure high image quality while maximizing the number of institutions meeting the acquisition requirements. In recent years, extensive effort has been made by consensus groups to propose different “ideal” and “minimum requirements” brain tumor imaging protocols (BTIPs) for gliomas, brain metastases (BM), and primary central nervous system lymphomas (PCSNL). In clinical practice, BTIPs for clinical trials can be easily integrated with additional MRI sequences that may be desired for clinical patient management at individual sites. In this review, we summarize the general concepts behind the choice and timing of sequences included in the current recommended BTIPs, we provide a comparative overview, and discuss tips and caveats to integrate additional clinical or research sequences while preserving the recommended BTIPs. Finally, we also reflect on potential future directions for brain tumor imaging in clinical trials.
AB - Standardized MRI acquisition protocols are crucial for reducing the measurement and interpretation variability associated with response assessment in brain tumor clinical trials. The main challenge is that standardized protocols should ensure high image quality while maximizing the number of institutions meeting the acquisition requirements. In recent years, extensive effort has been made by consensus groups to propose different “ideal” and “minimum requirements” brain tumor imaging protocols (BTIPs) for gliomas, brain metastases (BM), and primary central nervous system lymphomas (PCSNL). In clinical practice, BTIPs for clinical trials can be easily integrated with additional MRI sequences that may be desired for clinical patient management at individual sites. In this review, we summarize the general concepts behind the choice and timing of sequences included in the current recommended BTIPs, we provide a comparative overview, and discuss tips and caveats to integrate additional clinical or research sequences while preserving the recommended BTIPs. Finally, we also reflect on potential future directions for brain tumor imaging in clinical trials.
KW - brain tumor imaging protocols
KW - brain tumors
KW - BTIP
KW - clinical trials
KW - neuro-oncology
KW - RANO criteria
KW - treatment response assessment
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U2 - 10.3389/fradi.2023.1267615
DO - 10.3389/fradi.2023.1267615
M3 - Review article
AN - SCOPUS:85183618226
SN - 2673-8740
VL - 3
JO - Frontiers in Radiology
JF - Frontiers in Radiology
M1 - 1267615
ER -