Abstract
Sporadic late onset nemaline myopathy (SLONM) is a progressive myopathy of indeterminate etiology and poor outcome. If associated with a monoclonal gammopathy, SLONM carries a more unfavorable prognosis. Immunotherapy was unsuccessful. We report two HIV-negative SLONM/ monoclonal gammopathy patients who improved following intravenous immunoglobulin (IVIg) treatment alone or in combination with immunosuppressant agents. This favorable response to treatment suggests that a dysimmune mechanism is operative in some SLONM individuals. We suggest that IVIg deserves initial consideration for SLONM therapy.
Original language | English (US) |
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Pages (from-to) | 272-276 |
Number of pages | 5 |
Journal | Muscle and Nerve |
Volume | 41 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2010 |
Keywords
- IVIg
- Monoclonal gammopathy
- Nemaline myopathy
ASJC Scopus subject areas
- Physiology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Physiology (medical)