Spontaneous polymerization of the antibiotic peptide magainin 2

Raul Urrutia, Ricardo A. Cruciani, Jeffery L. Barker, Bechara Kachar

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


We describe here the ability of the magainin 2 peptide to assemble spontaneously into characteristic 13-nm diameter filaments having a 30 nm periodic helical substructure. Optimal conditions for extensive polymerization into filaments of several hundred microns required low pH and high ionic strength. Polymerization of the magainin 2 peptide may be involved in its recently described in vitro membrane-disrupting and antibiotic activities.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalFEBS Letters
Issue number1
StatePublished - Apr 10 1989


  • Antibiotic mechanism
  • Electron microscopy
  • Magainin 2
  • Polymerization

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


Dive into the research topics of 'Spontaneous polymerization of the antibiotic peptide magainin 2'. Together they form a unique fingerprint.

Cite this