Spontaneous Calcium Waves without Contraction in Cardiac Myocytes

José R. López, Aleksandar Jovanovic, Andre Terzic

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Spontaneous Ca2+ waves were visualized in quiescent cardiomyocytes loaded with the Ca2+-sensitive fluorescent probe, Fluo-3, and imaged by laser confocal microscopy. No sarcomere shortening was detected during wave propagation. This type of Ca2+ waves began at the periphery or in a central region of a myocyte and propagated the length of the cell in one or two directions. The average velocity of wave propagation was 32 μm/sec and the estimated concentration of Ca2+ oscillated from 124, at the bottom, to 311 nM, at the pick of the wave. Ca2+ waves were not confined to a single cell but could spread from cell to cell. These results describe a type of spontaneous Ca2+ waves which does not induce a contractile response in cardiomyocytes.

Original languageEnglish (US)
Pages (from-to)781-787
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number3
StatePublished - 1995

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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