TY - JOUR
T1 - Spontaneous Calcium Waves without Contraction in Cardiac Myocytes
AU - López, José R.
AU - Jovanovic, Aleksandar
AU - Terzic, Andre
PY - 1995
Y1 - 1995
N2 - Spontaneous Ca2+ waves were visualized in quiescent cardiomyocytes loaded with the Ca2+-sensitive fluorescent probe, Fluo-3, and imaged by laser confocal microscopy. No sarcomere shortening was detected during wave propagation. This type of Ca2+ waves began at the periphery or in a central region of a myocyte and propagated the length of the cell in one or two directions. The average velocity of wave propagation was 32 μm/sec and the estimated concentration of Ca2+ oscillated from 124, at the bottom, to 311 nM, at the pick of the wave. Ca2+ waves were not confined to a single cell but could spread from cell to cell. These results describe a type of spontaneous Ca2+ waves which does not induce a contractile response in cardiomyocytes.
AB - Spontaneous Ca2+ waves were visualized in quiescent cardiomyocytes loaded with the Ca2+-sensitive fluorescent probe, Fluo-3, and imaged by laser confocal microscopy. No sarcomere shortening was detected during wave propagation. This type of Ca2+ waves began at the periphery or in a central region of a myocyte and propagated the length of the cell in one or two directions. The average velocity of wave propagation was 32 μm/sec and the estimated concentration of Ca2+ oscillated from 124, at the bottom, to 311 nM, at the pick of the wave. Ca2+ waves were not confined to a single cell but could spread from cell to cell. These results describe a type of spontaneous Ca2+ waves which does not induce a contractile response in cardiomyocytes.
UR - http://www.scopus.com/inward/record.url?scp=0028866206&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028866206&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1995.2354
DO - 10.1006/bbrc.1995.2354
M3 - Article
C2 - 7575544
AN - SCOPUS:0028866206
SN - 0006-291X
VL - 214
SP - 781
EP - 787
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -