Soft tissue sarcoma stiffness and perfusion evaluation by MRE and DCE-MRI for radiation therapy response assessment: A technical feasibility study

Kay Pepin; Roger Grimm; Soudabeh Kargar; B. Matthew Howe; Karen Fritchie; Matthew Frick; Doris Wenger; Scott Okuno; Richard Ehman; Kiaran McGee; Sarah James; Nadia Laack; Michael Herman; Deanna Pafundi

doi:10.1088/2057-1976/ab2175

Soft tissue sarcoma stiffness and perfusion evaluation by MRE and DCE-MRI for radiation therapy response assessment: A technical feasibility study

Kay Pepin, Roger Grimm, Soudabeh Kargar, B. Matthew Howe, Karen Fritchie, Matthew Frick, Doris Wenger, Scott Okuno, Richard Ehman, Kiaran McGee, Sarah James, Nadia Laack, Michael Herman, Deanna Pafundi

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Abstract

Soft tissue sarcomas are a rare and heterogeneous group of malignancies that present significant diagnostic and therapeutic challenges. Patient stratification based on tumor aggressiveness and early therapeutic response based on quantitative imaging may improve prediction of treatment response and the evaluation of new treatment strategies in clinical trials. The purpose of this pilot study was to determine the technical feasibility of magnetic resonance elastography (MRE) and dynamic contrast-enhanced (DCE) MRI for the evaluation of sarcoma stiffness and perfusion in 9 patients with histologically confirmed sarcoma. Additionally, we assessed the feasibility of utilizing MRE and DCE-MRI for the early evaluation of response to radiation therapy in 4 patients to determine the utility of further evaluation in a larger cohort study. Tumor size, stiffness, and perfusion parameters all decreased from baseline at the time of the pre-surgery or follow-up MRI, and results were compared to pathology or conventional imaging. MRE and DCE-MRI may be useful for the quantitative evaluation of tumor stiffness and perfusion, and therapy response assessment in soft tissue sarcomas.

Original language	English (US)
Article number	047003
Journal	Biomedical Physics and Engineering Express
Volume	5
Issue number	4
DOIs	https://doi.org/10.1088/2057-1976/ab2175
State	Published - May 2 2019

Keywords

DCE-MRI
magnetic resonance elastography
perfusion
radiation therapy
response assessment
sarcoma
stiffness

ASJC Scopus subject areas

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10.1088/2057-1976/ab2175

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Pepin, K., Grimm, R., Kargar, S., Howe, B. M., Fritchie, K., Frick, M., Wenger, D., Okuno, S., Ehman, R., McGee, K., James, S., Laack, N., Herman, M., & Pafundi, D. (2019). Soft tissue sarcoma stiffness and perfusion evaluation by MRE and DCE-MRI for radiation therapy response assessment: A technical feasibility study. Biomedical Physics and Engineering Express, 5(4), Article 047003. https://doi.org/10.1088/2057-1976/ab2175

Pepin, K, Grimm, R, Kargar, S, Howe, BM, Fritchie, K, Frick, M, Wenger, D, Okuno, S , Ehman, R , McGee, K, James, S, Laack, N, Herman, M & Pafundi, D 2019, 'Soft tissue sarcoma stiffness and perfusion evaluation by MRE and DCE-MRI for radiation therapy response assessment: A technical feasibility study', Biomedical Physics and Engineering Express, vol. 5, no. 4, 047003. https://doi.org/10.1088/2057-1976/ab2175

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title = "Soft tissue sarcoma stiffness and perfusion evaluation by MRE and DCE-MRI for radiation therapy response assessment: A technical feasibility study",

abstract = "Soft tissue sarcomas are a rare and heterogeneous group of malignancies that present significant diagnostic and therapeutic challenges. Patient stratification based on tumor aggressiveness and early therapeutic response based on quantitative imaging may improve prediction of treatment response and the evaluation of new treatment strategies in clinical trials. The purpose of this pilot study was to determine the technical feasibility of magnetic resonance elastography (MRE) and dynamic contrast-enhanced (DCE) MRI for the evaluation of sarcoma stiffness and perfusion in 9 patients with histologically confirmed sarcoma. Additionally, we assessed the feasibility of utilizing MRE and DCE-MRI for the early evaluation of response to radiation therapy in 4 patients to determine the utility of further evaluation in a larger cohort study. Tumor size, stiffness, and perfusion parameters all decreased from baseline at the time of the pre-surgery or follow-up MRI, and results were compared to pathology or conventional imaging. MRE and DCE-MRI may be useful for the quantitative evaluation of tumor stiffness and perfusion, and therapy response assessment in soft tissue sarcomas.",

keywords = "DCE-MRI, magnetic resonance elastography, perfusion, radiation therapy, response assessment, sarcoma, stiffness",

author = "Kay Pepin and Roger Grimm and Soudabeh Kargar and Howe, {B. Matthew} and Karen Fritchie and Matthew Frick and Doris Wenger and Scott Okuno and Richard Ehman and Kiaran McGee and Sarah James and Nadia Laack and Michael Herman and Deanna Pafundi",

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AU - Howe, B. Matthew

AU - Fritchie, Karen

AU - Frick, Matthew

AU - Wenger, Doris

AU - Okuno, Scott

AU - Ehman, Richard

AU - McGee, Kiaran

AU - James, Sarah

AU - Laack, Nadia

AU - Herman, Michael

AU - Pafundi, Deanna

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N2 - Soft tissue sarcomas are a rare and heterogeneous group of malignancies that present significant diagnostic and therapeutic challenges. Patient stratification based on tumor aggressiveness and early therapeutic response based on quantitative imaging may improve prediction of treatment response and the evaluation of new treatment strategies in clinical trials. The purpose of this pilot study was to determine the technical feasibility of magnetic resonance elastography (MRE) and dynamic contrast-enhanced (DCE) MRI for the evaluation of sarcoma stiffness and perfusion in 9 patients with histologically confirmed sarcoma. Additionally, we assessed the feasibility of utilizing MRE and DCE-MRI for the early evaluation of response to radiation therapy in 4 patients to determine the utility of further evaluation in a larger cohort study. Tumor size, stiffness, and perfusion parameters all decreased from baseline at the time of the pre-surgery or follow-up MRI, and results were compared to pathology or conventional imaging. MRE and DCE-MRI may be useful for the quantitative evaluation of tumor stiffness and perfusion, and therapy response assessment in soft tissue sarcomas.

AB - Soft tissue sarcomas are a rare and heterogeneous group of malignancies that present significant diagnostic and therapeutic challenges. Patient stratification based on tumor aggressiveness and early therapeutic response based on quantitative imaging may improve prediction of treatment response and the evaluation of new treatment strategies in clinical trials. The purpose of this pilot study was to determine the technical feasibility of magnetic resonance elastography (MRE) and dynamic contrast-enhanced (DCE) MRI for the evaluation of sarcoma stiffness and perfusion in 9 patients with histologically confirmed sarcoma. Additionally, we assessed the feasibility of utilizing MRE and DCE-MRI for the early evaluation of response to radiation therapy in 4 patients to determine the utility of further evaluation in a larger cohort study. Tumor size, stiffness, and perfusion parameters all decreased from baseline at the time of the pre-surgery or follow-up MRI, and results were compared to pathology or conventional imaging. MRE and DCE-MRI may be useful for the quantitative evaluation of tumor stiffness and perfusion, and therapy response assessment in soft tissue sarcomas.

KW - DCE-MRI

KW - magnetic resonance elastography

KW - perfusion

KW - radiation therapy

KW - response assessment

KW - sarcoma

KW - stiffness

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Soft tissue sarcoma stiffness and perfusion evaluation by MRE and DCE-MRI for radiation therapy response assessment: A technical feasibility study

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