Sodium iodide symporter (NIS) gene expression in human placenta

A. M. Mitchell, S. W. Manley, J. C. Morris, K. A. Powell, E. R. Bergert, R. H. Mortimer

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


The placenta must allow the passage of iodide from the maternal to the fetal circulation for synthesis of thyroxine by the fetal thyroid. The thyroid sodium iodide symporter (NIS) was cloned in 1996 and, although widely distributed among epithelial tissues, early studies failed to detect it in placenta. We demonstrated NIS mRNA in human placenta and in the human choriocarcinoma cell line, JAr. NIS protein was localized to trophoblasts, with a tendency to apical distribution, in sections of human placenta immunostained with a monoclonal antibody against hNIS. We conclude that NIS is expressed in placenta and may mediate placental iodide transport.

Original languageEnglish (US)
Pages (from-to)256-258
Number of pages3
Issue number2-3
StatePublished - 2001

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology


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