@article{4e42a6824f6a464ebbcc105b11341496,
title = "SNIP1 Is a Candidate Modifier of the Transcriptional Activity of c-Myc on E Box-Dependent Target Genes",
abstract = "Using a yeast two-hybrid screen, we found that SNIP1 (Smad nuclear-interacting protein 1) associates with c-Myc, a key regulator of cell proliferation and transformation. We demonstrate that SNIP1 functions as an important regulator of c-Myc activity, binding the N terminus of c-Myc through its own C terminus, and that SNIP1 enhances the transcriptional activity of c-Myc both by stabilizing it against proteosomal degradation and by bridging the c-Myc/p300 complex. These effects of SNIP1 on c-Myc likely contribute to synergistic effects of SNIP1, c-Myc, and H-Ras in inducing formation of foci in an in vitro transformation assay and also in supporting anchorage-independent growth. The significant association of SNIP1 and c-Myc staining in a non-small cell lung cancer tissue array is further evidence that their activities might be linked and suggests that SNIP1 might be an important modulator of c-Myc activity in carcinogenesis.",
keywords = "CELLCYCLE, DNA",
author = "Makiko Fujii and Lyakh, {Lyudmila A.} and Bracken, {Cameron P P.} and Junya Fukuoka and Morisada Hayakawa and Tadasuke Tsukiyama and Soll, {Steven J J.} and Melissa Harris and Sonia Rocha and Roche, {Kevin C C.} and Tominaga, {Shin ichi} and Jin Jen and Perkins, {Neil D D.} and Lechleider, {Robert J.} and Roberts, {Anita B B.}",
note = "Funding Information: We thank H. Ariga, S. Kyo, R.J. Davis, K. Nakayama, S. Hatakeyama, C.V. Dang, A.K. Kamaraju, X.H. Feng, and A. Glick for providing invaluable reagents, and S. Kajigaya, B. Tang, and J.N. Brady for fruitful discussions. We thank M.M. Sharp and S. Peterson for technical help. M.F. thanks the Japan Society for the Promotion of Science and Jichi Medical University Young Investigator Award for support during the course of this work. C.P.B. and S.R. were supported by Cancer Research UK program grant C1443/A5435, while K.C.R. received funding from the BBSRC and AICR. This research was supported, in part, by the Intramural Research Program of the National Cancer Institute, NIH. This work is dedicated to the memory of Anita Roberts, our mentor, colleague, and, above all, dear friend. ",
year = "2006",
month = dec,
day = "8",
doi = "10.1016/j.molcel.2006.11.006",
language = "English (US)",
volume = "24",
pages = "771--783",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "5",
}