Smoldering multiple myeloma: Reviewing the rationale for intervention

Research output: Contribution to journalReview articlepeer-review


Smoldering multiple myeloma has been recognized for over 40 years and represents a pre-symptomatic phase of the 2nd most common hematologic malignancy. 1/3 of patients will remain asymptomatic at 10 years. There is an identifiable subset of patients that will develop CRAB within 2 years of recognition and these patients are considered for therapeutic intervention before the development of potentially irreversible complications. Obstacles to widespread implementation of therapeutic guidelines are limited by the variable definitions associated with this high-risk group as well as the poor concordance between classification schemes. Analysis of clinical trial outcomes as well as uniform eligibility helps determine whether a given patient should be considered for therapeutic intervention outside of a clinical trial.

Original languageEnglish (US)
Pages (from-to)2033-2040
Number of pages8
JournalLeukemia and Lymphoma
Issue number9
StatePublished - 2022


  • Monoclonal gammopathy undetermined significance
  • chemoprevention
  • multiple myeloma
  • myeloma defining events
  • smoldering multiple myeloma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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