SMART: Stroke-like migraine attacks after radiation therapy

D. F. Black, J. D. Bartleson, M. L. Bell, D. H. Lachance

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


We describe two adults with stroke-like migraine attacks after radiation therapy (SMART syndrome), propose revised diagnostic criteria, and review the previously reported patients. 'SMART' is an acronym for a newly recognized syndrome which occurs as a delayed consequence of cerebral irradiation and consists of prolonged, unilateral, migrainous neurological symptoms with transient, dramatic cortical gadolinium enhancement of the affected cerebral hemisphere and is sometimes punctuated by generalized seizures and ipsilateral EEG slowing. Although the neurological symptoms can last for weeks, full recovery occurs. An appropriate evaluation should exclude alternative explanations.

Original languageEnglish (US)
Pages (from-to)1137-1142
Number of pages6
Issue number9
StatePublished - Sep 2006


  • MRI brain scan
  • Migraine
  • Radiation therapy
  • Seizure
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology


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