Abstract
In Lewy body dementia (LBD), disturbances of sleep and/or arousal including insomnia, excessive daytime sleepiness, rapid eye movement (REM) sleep behavior disorder, obstructive sleep apnea, and restless leg syndrome are common. These disorders can each exert a significant negative impact on both patient and caregiver quality of life; however, their etiology is poorly understood. Little guidance is available for assessing and managing sleep disorders in LBD, and they remain under-diagnosed and under-treated. This review aims to (1) describe the specific sleep disorders which occur in LBD, considering their putative or potential mechanisms; (2) describe the history and diagnostic process for these disorders in LBD; and (3) summarize current evidence for their management in LBD and consider some of the ongoing and unanswered questions in this field and future research directions.
Original language | English (US) |
---|---|
Pages (from-to) | 5264-5283 |
Number of pages | 20 |
Journal | Alzheimer's and Dementia |
Volume | 19 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2023 |
Keywords
- Lewy body dementia
- Parkinson's disease dementia
- daytime somnolence
- dementia with Lewy bodies
- excessive daytime sleepiness
- insomnia
- obstructive sleep apnea
- rapid eye movement sleep behavior disorder
- restless leg syndrome
- sleep
- sleep disorders
- sleep disturbance
ASJC Scopus subject areas
- Epidemiology
- Health Policy
- Developmental Neuroscience
- Clinical Neurology
- Geriatrics and Gerontology
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health