Sleep apnea, hypertension and the sympathetic nervous system in the adult population

Shreyas Venkataraman, Soumya Vungarala, Naima Covassin, Virend K. Somers

Research output: Contribution to journalReview articlepeer-review


Sleep apnea is very common in patients with cardiovascular disease, especially in patients with hypertension. Over the last few decades a number of discoveries have helped support a causal relationship between the two and even resistant hypertension. The role neurogenic mechanisms play has gathered more attention in the recent past due to their immediate bedside utility. Several innovative discoveries in pathogenesis including those exploring the role of baroreflex gain, cardiovascular variability, chemoreceptor reflex activation and the sympathetic nervous system have emerged. In this review, we discuss the epidemiology of sleep apnea and hypertension and the pathogenic mechanisms contributing to neurogenic hypertension. Furthermore, recent management strategies in addition to continuous positive airway pressure (CPAP), such as upper airway stimulation and renal denervation that target these pathogenic mechanisms, are also discussed.

Original languageEnglish (US)
Article number591
JournalJournal of Clinical Medicine
Issue number2
StatePublished - Feb 2020


  • Hypertension
  • Neurogenic
  • Obstructive sleep apnea
  • Resistant hypertension
  • Sleep apnea
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Medicine(all)


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