Sleep and Nocturnal Gastroesophageal Reflux: An Update

Kaiser G. Lim, Timothy I. Morgenthaler, David A. Katzka

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Nocturnal gastroesophageal reflux has been associated with poor sleep quality. Normal physiological adaptations of the aerodigestive system to sleep prolong and intensify nocturnal reflux events. This occurrence leads to sleep disruption, as well as to esophageal, laryngeal, and laryngopharyngeal reflux. Controversy exists on whether OSA and nocturnal reflux are causally linked or merely associated because of shared risk factors. Advances in diagnostic technology have provided new insights into gastroesophageal reflux and the mechanisms of nocturnal reflux during sleep. This update reviews new data on causal links between sleep and gastroesophageal reflux disease.

Original languageEnglish (US)
Pages (from-to)963-971
Number of pages9
Issue number4
StatePublished - Oct 2018


  • CPAP
  • OSA
  • gastroesophageal reflux disease
  • lower esophageal sphincter
  • nocturnal acid breakthrough
  • sleep
  • transient lower esophageal sphincter relaxation
  • upper esophageal sphincter

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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