TY - JOUR
T1 - Skin cancer after pancreas transplantation
AU - Spanogle, Joshua P.
AU - Kudva, Yogish C.
AU - Dierkhising, Ross A.
AU - Kremers, Walter K.
AU - Roenigk, Randall K.
AU - Brewer, Jerry D.
AU - Prieto, Mikel
AU - Otley, Clark C.
PY - 2012/10
Y1 - 2012/10
N2 - Background: Skin cancer in patients who have undergone pancreas transplantation (PT) has not been extensively characterized. Objective: We sought to describe the incidence, tumor burden, and risk factors for skin cancer in PT recipients at Mayo Clinic from 1998 through 2006. Methods: A retrospective study was performed by analyzing outcomes among a cohort of pancreas allograft recipients at Mayo Clinic between 1998 and 2006. Results: Among 216 allogeneic PT recipients at 2, 5, and 10 years posttransplantation, the cumulative incidence of any skin cancer was 4.7%, 12.7%, and 19.6%; the cumulative incidence of squamous cell carcinoma was 2.8%, 10.3%, and 16.7%; and the cumulative incidence of basal cell carcinoma was 2.4%, 7.8%, and 17.4%, respectively. The cumulative incidence of a second squamous cell carcinoma developing was 56% at 2 years; the cumulative incidence of a second basal cell carcinoma developing was 36% at 2 years. Of the risk factors examined, only age and having a skin cancer before transplantation were predictive of skin cancer development. Limitations: This was a retrospective study. Results from a large tertiary center may not be generalizable. Conclusions: Nonmelanoma skin cancers commonly occur in recipients of PT, and those patients who have a history of nonmelanoma skin cancer have a very high likelihood of further skin cancer development.
AB - Background: Skin cancer in patients who have undergone pancreas transplantation (PT) has not been extensively characterized. Objective: We sought to describe the incidence, tumor burden, and risk factors for skin cancer in PT recipients at Mayo Clinic from 1998 through 2006. Methods: A retrospective study was performed by analyzing outcomes among a cohort of pancreas allograft recipients at Mayo Clinic between 1998 and 2006. Results: Among 216 allogeneic PT recipients at 2, 5, and 10 years posttransplantation, the cumulative incidence of any skin cancer was 4.7%, 12.7%, and 19.6%; the cumulative incidence of squamous cell carcinoma was 2.8%, 10.3%, and 16.7%; and the cumulative incidence of basal cell carcinoma was 2.4%, 7.8%, and 17.4%, respectively. The cumulative incidence of a second squamous cell carcinoma developing was 56% at 2 years; the cumulative incidence of a second basal cell carcinoma developing was 36% at 2 years. Of the risk factors examined, only age and having a skin cancer before transplantation were predictive of skin cancer development. Limitations: This was a retrospective study. Results from a large tertiary center may not be generalizable. Conclusions: Nonmelanoma skin cancers commonly occur in recipients of PT, and those patients who have a history of nonmelanoma skin cancer have a very high likelihood of further skin cancer development.
KW - basal cell carcinoma
KW - immunosuppression
KW - kidney transplantation
KW - pancreas transplantation
KW - skin cancer
KW - squamous cell carcinoma
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U2 - 10.1016/j.jaad.2011.11.939
DO - 10.1016/j.jaad.2011.11.939
M3 - Article
C2 - 22341468
AN - SCOPUS:84866395862
SN - 0190-9622
VL - 67
SP - 563
EP - 569
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 4
ER -