Abstract
Background: Cervical ectopic pregnancies (CEPs) are increasingly being managed conservatively. However, the efficacy of specific conservative approaches such as the single-dose intramuscular (IM) methotrexate (MTX) therapy has not been evaluated. We report the successful management of 2 consecutive CEPs in the same patient with single-dose IM MTX therapy, and review published cases of CEPs treated with a similar regimen, to determine the efficacy of this approach. CASE: In our case, both CEPs resolved with single-dose IM MTX, and the patient subsequently had a successful term delivery. A Medline/OVID English language search, covering the period 1982–2012, identified 38 additional cases of CEPs treated with single-dose IM MTX. Of the total 40 cases analyzed, including our 2 cases, 30 (75%) were successfully treated, with complete remission. Of the 27 cases with no embryonic cardiac activity, 25 (93%) were successfully treated with single-dose IM MTX. Conclusion: Appropriately selected cases of CEPs can be successfully managed with single-dose IM MTX with very low complication rates and preservation of future fertility potential.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 78-82 |
| Number of pages | 5 |
| Journal | The Journal of reproductive medicine |
| Volume | 60 |
| Issue number | 1 |
| State | Published - Feb 1 2015 |
Keywords
- Cervical pregnancy
- Ectopic pregnancy
- Embryo transfer
- Methotrexate
- Recurrent ectopic pregnancy
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Reproductive Medicine