TY - JOUR
T1 - Side chain oxidation of 25-hydroxy-[26,27-14C]vitamin D3 and 1,25-dihydroxy-[26,27-14C]vitamin D3 in vivo by chickens
AU - Kumar, Rajiv
AU - DeLuca, H. F.
N1 - Funding Information:
+This work was supported by PHS grant No. ~-14881 of the Wisconsin Alumni Research Foundation.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1976/3/8
Y1 - 1976/3/8
N2 - Radio carbon dioxide was detected in expired air of vitamin D-deficient chicks administered either 25-hydroxy-[26,27-14C]vitamin D3 or 1,25-dihydroxy-[26,27-14C]vitamin D3 intravenously. At 48 hours the amounts were 5.13 ± 1.02% and 11.8 ± 3.10% of the administered dose, respectively. This phenomenon, similar to the one observed in rats, represents side chain oxidation and elimination of either one or both of the 26 and 27 carbons from the viamin D molecule. The observation that the rate of 14CO2 evolution is maximal 4 hours after a dose of 1,25-dihydroxy-[26,27-14C]vitamin D3 suggests that this pathway may be of importance to the function of 1,25-dihydroxyvitamin D3.
AB - Radio carbon dioxide was detected in expired air of vitamin D-deficient chicks administered either 25-hydroxy-[26,27-14C]vitamin D3 or 1,25-dihydroxy-[26,27-14C]vitamin D3 intravenously. At 48 hours the amounts were 5.13 ± 1.02% and 11.8 ± 3.10% of the administered dose, respectively. This phenomenon, similar to the one observed in rats, represents side chain oxidation and elimination of either one or both of the 26 and 27 carbons from the viamin D molecule. The observation that the rate of 14CO2 evolution is maximal 4 hours after a dose of 1,25-dihydroxy-[26,27-14C]vitamin D3 suggests that this pathway may be of importance to the function of 1,25-dihydroxyvitamin D3.
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U2 - 10.1016/S0006-291X(76)80291-4
DO - 10.1016/S0006-291X(76)80291-4
M3 - Article
C2 - 1259757
AN - SCOPUS:0017236224
SN - 0006-291X
VL - 69
SP - 197
EP - 200
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -