Sex differences in translocator protein 18 kDa (TSPO) in the heart: Implications for imaging myocardial inflammation

De Lisa Fairweather, Michael J. Coronado, Amanda E. Garton, Jennifer L. Dziedzic, Adriana Bucek, Leslie T. Cooper, Jessica E. Brandt, Fatima S. Alikhan, Haofan Wang, Christopher J. Endres, Judy Choi, Martin G. Pomper, Tomás R. Guilarte

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Myocarditis is more severe in men than in women and difficult to diagnose due to a lack of imaging modalities that directly detect myocardial inflammation. Translocator protein 18 kDa (TSPO) is used extensively to image brain inflammation due to its presence in CD11b+ brain microglia. In this study, we examined expression of TSPO and CD11b in mice with coxsackievirus B3 (CVB3) myocarditis and biopsy sections from myocarditis patients in order to determine if it could be used to image myocarditis. We found that male mice with CVB3 myocarditis upregulated more genes associated with TSPO activation than female mice. TSPO expression was increased in the heart of male mice and men with myocarditis compared with female subjects due to testosterone, where it was expressed predominantly in CD11b+ immune cells. We show that TSPO ligands detect myocardial inflammation using microSPECT, with increased uptake of [125I]-IodoDPA-713 in male mice with CVB3 myocarditis compared with undiseased controls.

Original languageEnglish (US)
Pages (from-to)192-202
Number of pages11
JournalJournal of cardiovascular translational research
Issue number2
StatePublished - Mar 2014


  • CD11b
  • Imaging
  • Myocarditis
  • Sex differences
  • Single-photon emission computed tomography
  • TSPO

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)


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