Severity of childhood asthma and human leukocyte antigens type

Young J. Juhn, Hirohito Kita, Stephanie M. Bagniewski, Amy L. Weaver, V. Shane Pankratz, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


We sought to learn if Class II HLA genes are associated with the severity of asthma in children. We examined a previously recruited cohort of 340 healthy children who had Class II HLA allele data available. We conducted a comprehensive review of their medical records to determine asthma status and, when present, its severity. We found that Class II HLA alleles, which were previously reported to have an association with asthma incidence, appear to have an association as well with asthma severity. These data support our hypothesis that both the incidence and severity of asthma are heritable and that HLA may play an important role in both development and severity of asthma. Because of limited statistical power, our study findings are subject to further investigation.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalJournal of Asthma
Issue number3
StatePublished - Apr 2007


  • Asthma
  • Genetics
  • HLA antigens
  • Predisposition
  • Severity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine


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