Severe/uncontrolled asthma and overall survival in atopic patients with eosinophilic granulomatosis with polyangiitis

Alvise Berti, Gerald W. Volcheck, Divi Cornec, Robert J. Smyth, Ulrich Specks, Karina A. Keogh

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: Although asthma, rhinitis/rhinosinusitis and peripheral eosinophilia are present in virtually all patients with eosinophilic granulomatosis with polyangiitis (EGPA), the role of atopy in these patients is not well defined. Objective: To clarify the role of atopy in patients affected with EGPA. Methods: Clinical, laboratory and standard spirometry data have been abstracted from medical records. Only patients who underwent skin and/or specific IgE testing for common aeroallergens before the vasculitic phase were included. Results: Overall, 33.5% (63) of our patients underwent skin and/or specific IgE testing to aeroallergens. Atopy related to aeroallergens was confirmed in 22.3% (two-third of those tested), and was associated with more severe/uncontrolled asthma (p < 0.001), including a greater use of oral glucocorticoids for respiratory manifestations the year before the diagnosis of EGPA (p = 0.013). Atopic patients with EGPA had higher total serum IgE levels and less renal disease at EGPA diagnosis compared to non-atopic patients (p < 0.05). Among atopic patients, the majority had multiple sensitizations (76%); dust mite and grass pollen were the most common respiratory allergens identified. The number of allergens did not correlate with peripheral eosinophilia, total serum IgE, ESR, or measures of airway obstruction (p > 0.05 in all cases). The presence of atopy increased the risk of severe/uncontrolled asthma, but not the risk of severe vasculitis (Five Factor Score≥1). Atopic patients had a better overall survival (p = 0.027). Conclusion: In EGPA, atopy is associated with better prognosis and more severe/uncontrolled asthma manifestations in the year before the development of vasculitis, but not with more severe vasculitis at presentation.

Original languageEnglish (US)
Pages (from-to)66-72
Number of pages7
JournalRespiratory Medicine
StatePublished - Sep 2018


  • ANCA-Associated vasculitis
  • Asthma
  • Atopy
  • Churg-strauss
  • EGPA
  • Eosinophilic granulomatosis with polyangiitis
  • Severe asthma
  • Skin test
  • Specific IgE
  • Survival

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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