Severe vitamin B12 deficiency resulting in pancytopenia, splenomegaly and leukoerythroblastosis

Thorvardur R. Halfdanarson, James A. Walker, Mark R. Litzow, Curtis A. Hanson

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Deficiency of vitamin B12 is a well known cause of megaloblastic anemia and pancytopenia. Splenomegaly and leukoerythroblastosis are much less well known manifestations of B12 deficiency. We report a B12 deficient female with severe pancytopenia including normocytic anemia who also had enlarged spleen and circulating nucleated red blood cells as well as circulating immature myeloid cells. Although these findings are reported in the earlier literature, more modern reviews of the subject often fail to mention this association. We review the literature on these unusual manifestations of B12 deficiency and remind clinicians that splenomegaly and erythroblastosis can serve as diagnostic clues in cases of severe megaloblastic anemia secondary to B12 deficiency.

Original languageEnglish (US)
Pages (from-to)448-451
Number of pages4
JournalEuropean Journal of Haematology
Issue number5
StatePublished - May 2008


  • B12 deficiency
  • Leukoerythroblastosis
  • Pancytopenia
  • Pernicious anemia
  • Splenomegaly

ASJC Scopus subject areas

  • Hematology


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