Severe cholestasis related to itraconazole for the treatment of onychomycosis

Jayant A. Talwalkar, Roy E. Soetikno, David L. Carr-Locke, Carl L. Berg

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


We describe a case of prolonged cholestasis temporally associated with the use of itraconazole for onychomycosis. Peak bilirubin level of 32.0 mg/dl was documented approximately 2 months after discontinuation of the patient's itraconazole therapy, with symptoms of cholestasis persisting more than 1 month after the peak in bilirubin. Physicians should be aware of the potential for severe cholestasis associated with itraconazole usage.

Original languageEnglish (US)
Pages (from-to)3632-3633
Number of pages2
JournalAmerican Journal of Gastroenterology
Issue number12
StatePublished - Dec 1 1999

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'Severe cholestasis related to itraconazole for the treatment of onychomycosis'. Together they form a unique fingerprint.

Cite this