Abstract
A 49-year-old previously healthy female presented with acute hepatitis and severe neutropenia. A diagnosis of type 1 autoimmune hepatitis was made based on the histological appearance of a liver core biopsy, positive anti-smooth muscle antibodies, and positive anti-neutrophil cytoplasmic antibody (atypical ANCA). Hemogram revealed mild leukopenia with severe neutropenia (absolute neutrophil count 256/mm3), normal hemoglobin and mild thrombocytopenia (115000/mm3). A bone marrow biopsy and aspirate had a normal karyotype, increase in granulopoiesis, prominence of promyelocytes (31%) and absence of mature granulocytes. Anti-neutrophil antibodies were detected in the patient's blood. Therapy was directed at the underlying hepatitis with resolution of neutropenia without the use of colony-stimulating factors.
Original language | English (US) |
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Pages (from-to) | 673-678 |
Number of pages | 6 |
Journal | International journal of hematology |
Volume | 91 |
Issue number | 4 |
DOIs | |
State | Published - May 2010 |
Keywords
- Autoimmune hepatitis
- Autoimmune neutropenia
- Immune neutropenia
- Neutropenia
- Neutrophil antibodies
ASJC Scopus subject areas
- Hematology