Abstract
A global serum proteomic analysis was performed using liquid chromatography coupled with tandem mass spectrometry to identify predictive biomarkers in hormone-sensitive prostate cancer patients undergoing androgen deprivation therapy. We identified 47 candidates and then performed network enrichment analysis, which implicated β estradiol, nuclear factor kappa-light-chain enhancer of activated B cells complex, and P38 mitogen-activated protein kinases complex pathways as candidate pathways with potential predictive biomarkers of androgen deprivation.
Original language | English (US) |
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Pages (from-to) | 248-253.e7 |
Journal | Clinical Genitourinary Cancer |
Volume | 17 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2019 |
Keywords
- Hormonal therapy
- Predictive factors
- Prostate cancer
- Proteomics
- Serum
ASJC Scopus subject areas
- Oncology
- Urology