Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population

Huy Quang Quach, Inna G. Ovsyannikova, Diane E. Grill, Nathaniel D. Warner, Gregory A. Poland, Richard B. Kennedy

Research output: Contribution to journalArticlepeer-review


As an extremely contagious pathogen, a high rate of vaccine coverage and the durability of vaccine-induced immunity are key factors to control and eliminate measles. Herein, we assessed the seroprevalence of antibodies specific to measles in a cohort of 1393 adults (20–44 years old). ELISA results showed a nontrivial proportion of 37.6% study subjects being negative for measles immunoglobulin G (IgG). We also found significant influences of sex and age of the study cohort on the IgG level. Our findings suggest that even within a highly vaccinated population, a subset of individuals may still have sub-optimal immunity against measles and potentially be susceptible during any future measles outbreaks.

Original languageEnglish (US)
Article number1859
Issue number11
StatePublished - Nov 2022


  • MMR vaccine
  • measles virus
  • seroprevalence
  • serosurveillance
  • waning immunity

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Drug Discovery
  • Infectious Diseases
  • Pharmacology (medical)


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