Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population

Huy Quang Quach; Inna G. Ovsyannikova; Diane E. Grill; Nathaniel D. Warner; Gregory A. Poland; Richard B. Kennedy

doi:10.3390/vaccines10111859

Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population

Huy Quang Quach, Inna G. Ovsyannikova, Diane E. Grill, Nathaniel D. Warner, Gregory A. Poland, Richard B. Kennedy

General Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

As an extremely contagious pathogen, a high rate of vaccine coverage and the durability of vaccine-induced immunity are key factors to control and eliminate measles. Herein, we assessed the seroprevalence of antibodies specific to measles in a cohort of 1393 adults (20–44 years old). ELISA results showed a nontrivial proportion of 37.6% study subjects being negative for measles immunoglobulin G (IgG). We also found significant influences of sex and age of the study cohort on the IgG level. Our findings suggest that even within a highly vaccinated population, a subset of individuals may still have sub-optimal immunity against measles and potentially be susceptible during any future measles outbreaks.

Original language	English (US)
Article number	1859
Journal	Vaccines
Volume	10
Issue number	11
DOIs	https://doi.org/10.3390/vaccines10111859
State	Published - Nov 2022

Keywords

MMR vaccine
measles virus
seroprevalence
serosurveillance
waning immunity

ASJC Scopus subject areas

Immunology
Pharmacology
Drug Discovery
Infectious Diseases
Pharmacology (medical)

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10.3390/vaccines10111859

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title = "Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population",

abstract = "As an extremely contagious pathogen, a high rate of vaccine coverage and the durability of vaccine-induced immunity are key factors to control and eliminate measles. Herein, we assessed the seroprevalence of antibodies specific to measles in a cohort of 1393 adults (20–44 years old). ELISA results showed a nontrivial proportion of 37.6% study subjects being negative for measles immunoglobulin G (IgG). We also found significant influences of sex and age of the study cohort on the IgG level. Our findings suggest that even within a highly vaccinated population, a subset of individuals may still have sub-optimal immunity against measles and potentially be susceptible during any future measles outbreaks.",

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T1 - Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population

AU - Quach, Huy Quang

AU - Ovsyannikova, Inna G.

AU - Grill, Diane E.

AU - Warner, Nathaniel D.

AU - Poland, Gregory A.

AU - Kennedy, Richard B.

PY - 2022/11

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N2 - As an extremely contagious pathogen, a high rate of vaccine coverage and the durability of vaccine-induced immunity are key factors to control and eliminate measles. Herein, we assessed the seroprevalence of antibodies specific to measles in a cohort of 1393 adults (20–44 years old). ELISA results showed a nontrivial proportion of 37.6% study subjects being negative for measles immunoglobulin G (IgG). We also found significant influences of sex and age of the study cohort on the IgG level. Our findings suggest that even within a highly vaccinated population, a subset of individuals may still have sub-optimal immunity against measles and potentially be susceptible during any future measles outbreaks.

AB - As an extremely contagious pathogen, a high rate of vaccine coverage and the durability of vaccine-induced immunity are key factors to control and eliminate measles. Herein, we assessed the seroprevalence of antibodies specific to measles in a cohort of 1393 adults (20–44 years old). ELISA results showed a nontrivial proportion of 37.6% study subjects being negative for measles immunoglobulin G (IgG). We also found significant influences of sex and age of the study cohort on the IgG level. Our findings suggest that even within a highly vaccinated population, a subset of individuals may still have sub-optimal immunity against measles and potentially be susceptible during any future measles outbreaks.

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KW - measles virus

KW - seroprevalence

KW - serosurveillance

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Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population

Abstract

Keywords

ASJC Scopus subject areas

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