Serial Bronchoalveolar Lavage Fluid Aspergillus Galactomannan and Treatment Response in Invasive Pulmonary Aspergillosis

Daniel Z.P. Friedman; Elitza S. Theel; Randall C. Walker; Holenarasipur R. Vikram; Raymund R. Razonable; Paschalis Vergidis

doi:10.1093/ofid/ofae114

Serial Bronchoalveolar Lavage Fluid Aspergillus Galactomannan and Treatment Response in Invasive Pulmonary Aspergillosis

Daniel Z.P. Friedman, Elitza S. Theel, Randall C. Walker, Holenarasipur R. Vikram, Raymund R. Razonable, Paschalis Vergidis

Research output: Contribution to journal › Article › peer-review

Abstract

We studied patients diagnosed with aspergillosis based on positive bronchoalveolar lavage (BAL) Aspergillus galactomannan (GM) who had follow-up BAL sampling within 180 days. GM trend and clinical outcome were concordant in only 60% (30/50). While useful for the initial diagnosis, BAL GM trending does not always correlate with treatment response.

Original language	English (US)
Article number	ofae114
Journal	Open Forum Infectious Diseases
Volume	11
Issue number	4
DOIs	https://doi.org/10.1093/ofid/ofae114
State	Published - Apr 1 2024

Keywords

aspergillosis
bronchoscopy
galactomannan
hematopoietic stem cell transplant
solid organ transplant

ASJC Scopus subject areas

Oncology
Infectious Diseases

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10.1093/ofid/ofae114

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abstract = "We studied patients diagnosed with aspergillosis based on positive bronchoalveolar lavage (BAL) Aspergillus galactomannan (GM) who had follow-up BAL sampling within 180 days. GM trend and clinical outcome were concordant in only 60% (30/50). While useful for the initial diagnosis, BAL GM trending does not always correlate with treatment response.",

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AU - Walker, Randall C.

AU - Vikram, Holenarasipur R.

AU - Razonable, Raymund R.

AU - Vergidis, Paschalis

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AB - We studied patients diagnosed with aspergillosis based on positive bronchoalveolar lavage (BAL) Aspergillus galactomannan (GM) who had follow-up BAL sampling within 180 days. GM trend and clinical outcome were concordant in only 60% (30/50). While useful for the initial diagnosis, BAL GM trending does not always correlate with treatment response.

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KW - bronchoscopy

KW - galactomannan

KW - hematopoietic stem cell transplant

KW - solid organ transplant

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Serial Bronchoalveolar Lavage Fluid Aspergillus Galactomannan and Treatment Response in Invasive Pulmonary Aspergillosis

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Keywords

ASJC Scopus subject areas

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