Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases

Shuling Song, Eric W.F. Lam, Tamara Tchkonia, James L. Kirkland, Yu Sun

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Aging is a major risk factor for numerous human pathologies, including cardiovascular, metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies. While our understanding of aging is far from complete, recent advances suggest that targeting fundamental aging processes can delay, prevent, or alleviate age-related disorders. Cellular senescence is physiologically beneficial in several contexts, but it has causal roles in multiple chronic diseases. New studies have illustrated the promising feasibility and safety to selectively ablate senescent cells from tissues, a therapeutic modality that holds potential for treating multiple chronic pathologies and extending human healthspan. Here, we review molecular links between cellular senescence and age-associated complications and highlight novel therapeutic avenues that may be exploited to target senescent cells in future geriatric medicine.

Original languageEnglish (US)
Pages (from-to)578-592
Number of pages15
JournalTrends in biochemical sciences
Issue number7
StatePublished - Jul 2020


  • SASP
  • cellular senescence
  • clinical trials
  • geroscience
  • senolytics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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