Semiautomated segmentation of polycystic kidneys in T2-weighted MR images

Timothy L. Kline, Marie E. Edwards, Panagiotis Korfiatis, Zeynettin Akkus, Vicente E. Torres, Bradley J. Erickson

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


OBJECTIVE. The objective of the present study is to develop and validate a fast, accurate, and reproducible method that will increase and improve institutional measurement of total kidney volume and thereby avoid the higher costs, increased operator processing time, and inherent subjectivity associated with manual contour tracing. MATERIALS AND METHODS. We d eveloped a s emiautomated s egmentation a pproach, known as the minimal interaction rapid organ segmentation (MIROS) method, which results in human interaction during measurement of total kidney volume on MR images being reduced to a few minutes. This software tool automatically steps through slices and requires rough definition of kidney boundaries supplied by the user. The approach was verified on T2-weighted MR images of 40 patients with autosomal dominant polycystic kidney disease of varying degrees of severity. RESULTS. The MIROS approach required less than 5 minutes of user interaction in all cases. When compared with the ground-truth reference standard, MIROS showed no significant bias and had low variability (mean ± 2 SD, 0.19% ± 6.96%). CONCLUSION. The MIROS method will greatly facilitate future research studies in which accurate and reproducible measurements of cystic organ volumes are needed.

Original languageEnglish (US)
Pages (from-to)605-613
Number of pages9
JournalAmerican Journal of Roentgenology
Issue number3
StatePublished - Sep 2016


  • Autosomal dominant polycystic kidney disease
  • Geodesic active contour
  • Planimetry
  • Stereology
  • Total kidney volume

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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