TY - GEN
T1 - Semantic Web Ontology and Data Integration
T2 - 15th World Congress on Health and Biomedical Informatics, MEDINFO 2015
AU - Liang, Chen
AU - Sun, Jingchun
AU - Tao, Cui
PY - 2015
Y1 - 2015
N2 - There remain significant difficulties selecting probable candidate drugs from existing databases. We describe an ontology-oriented approach to represent the nexus between genes, drugs, phenotypes, symptoms, and diseases from multiple information sources. We also report a case study in which we attempted to explore candidate drugs effective for bipolar disorder and epilepsy. We constructed an ontology incorporating knowledge between the two diseases and performed semantic reasoning tasks with the ontology. The results suggested 48 candidate drugs that hold promise for further breakthrough. The evaluation demonstrated the validity our approach. Our approach prioritizes the candidate drugs that have potential associations among genes, phenotypes and symptoms, and thus facilitates the data integration and drug repurposing in psychiatric disorders.
AB - There remain significant difficulties selecting probable candidate drugs from existing databases. We describe an ontology-oriented approach to represent the nexus between genes, drugs, phenotypes, symptoms, and diseases from multiple information sources. We also report a case study in which we attempted to explore candidate drugs effective for bipolar disorder and epilepsy. We constructed an ontology incorporating knowledge between the two diseases and performed semantic reasoning tasks with the ontology. The results suggested 48 candidate drugs that hold promise for further breakthrough. The evaluation demonstrated the validity our approach. Our approach prioritizes the candidate drugs that have potential associations among genes, phenotypes and symptoms, and thus facilitates the data integration and drug repurposing in psychiatric disorders.
KW - Data Integration
KW - Drug Repurposing
KW - Ontology
UR - http://www.scopus.com/inward/record.url?scp=84952002437&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84952002437&partnerID=8YFLogxK
U2 - 10.3233/978-1-61499-564-7-1051
DO - 10.3233/978-1-61499-564-7-1051
M3 - Conference contribution
AN - SCOPUS:84952002437
SN - 9781614995630
VL - 216
T3 - Studies in Health Technology and Informatics
SP - 1051
BT - Studies in Health Technology and Informatics
PB - IOS Press
Y2 - 19 August 2015 through 23 August 2015
ER -