Abstract
It is recognized that individuals with mild cognitive impairment (MCI) already demonstrate difficulty in aspects of daily functioning, which predicts disease progression. This study examined the relationship between self- versus informant-report of functional ability, and how those reports relate to objective disease measures across the disease spectrum (i.e. cognitively normal, MCI, Alzheimer's disease). A total of 1080 subjects with self- and/or informant-rated Everyday Cognition questionnaires were included. Objective measures included cognitive functioning, structural brain atrophy, cerebrospinal fluid abnormalities, and a marker of amyloid deposition using positron emission tomography with [18F]AV45 (florbetapir). Overall, informant-report was consistently more associated with objective markers of disease than self-report although self-reported functional status may still have some utility in early disease.
Original language | English (US) |
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Article number | 1918 |
Pages (from-to) | 1080-1089 |
Number of pages | 10 |
Journal | Alzheimer's and Dementia |
Volume | 11 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 2015 |
Keywords
- ADNI
- Alzheimer's disease
- Biomarkers
- Daily functioning
- Dementia
- Everyday function
- Informant-report
- Instrumental activities of daily living
- Mild cognitive impairment (MCI)
- Self-report
ASJC Scopus subject areas
- Clinical Neurology
- Geriatrics and Gerontology
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience
- Health Policy
- Developmental Neuroscience
- Epidemiology