Second primary tumors following tobacco dependence treatments among head and neck cancer patients

Yolanda I. Garces, Darrell R. Schroeder, Liza M. Nirelli, Gary A. Croghan, Ivana T. Croghan, Robert L. Foote, Richard D. Hurt

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


OBJECTIVES: To estimate the cumulative percentage of second primary tumors (SPTs) in head and neck (H&N) cancer patients and primary cancers in general Nicotine Dependence Center (NDC) population controls following tobacco dependence consultation seen between 1988 and 2001. METHODS: A 1:1 matched pair design and a stratified Cox proportional hazard model were used. General NDC population controls were matched on age, gender, and NDC consult (type and date) to the H&N cancer patients. The study population included 101 H&N cancer patients (66 male, 35 female) with mean (SD) age of 58.7 (10.1) years. RESULTS: Baseline demographics and length of follow-up were similar between groups. However, H&N cancer patients smoked more cigarettes per day than controls (P < 0.003). For H&N cancer patients, the median time from initial H&N cancer diagnosis to NDC consult was 7 months (range, 0-292 months). Following the NDC consult, 27 H&N cancer patients developed 32 SPTs; whereas among the controls, 12 patients developed 12 other cancers (P = 0.013). There was no difference in the development of non-tobacco-related cancers (P = 0.273). However, H&N cancer patients were more likely to develop tobacco-related cancers (P = 0.01). Furthermore, there was a trend where the H&N cancer patients who continued to use tobacco were more likely to develop tobacco-related cancers than those who remained abstinent (P = 0.10). CONCLUSIONS: These findings confirm that H&N cancer patients are more prone to the development of tobacco-related cancers. Further, these findings suggest that H&N cancer patients who stop using tobacco are able to decrease the development of tobacco-related SPTs.

Original languageEnglish (US)
Pages (from-to)531-539
Number of pages9
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Issue number5
StatePublished - Oct 2007


  • Head and neck neoplasms
  • Multiple primary
  • Neoplasms
  • Second primary neoplasms
  • Smoking cessation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Second primary tumors following tobacco dependence treatments among head and neck cancer patients'. Together they form a unique fingerprint.

Cite this