@article{e03e6aa61c08439a856e4e68f574011e,
title = "Screening for regenerative therapy responders in heart failure",
abstract = "Risk of outcome variability challenges therapeutic innovation. Selection of the most suitable candidates is predicated on reliable response indicators. Especially for emergent regenerative biotherapies, determinants separating success from failure in achieving disease rescue remain largely unknown. Accordingly, (pre)clinical development programs have placed increased emphasis on the multi-dimensional decoding of repair capacity and disease resolution, attributes defining responsiveness. To attain regenerative goals for each individual, phenotype-based patient selection is poised for an upgrade guided by new insights into disease biology, translated into refined surveillance of response regulators and deep learning-amplified clinical decision support.",
keywords = "biomarkers, deep learning, heart failure, heterogeneity, imaging, prediction, regenerative medicine, stem cells, stratification",
author = "Satsuki Yamada and Ryounghoon Jeon and Armin Garmany and Atta Behfar and Andre Terzic",
note = "Funding Information: Medicine, Center for Biomedical Discovery and Medical Scientist Training Program at Mayo Clinic. A Terzic holds the Marriott Family Professorship in Cardiovascular Diseases Research, and is Michael S and Mary Sue Shannon Director of the Mayo Clinic Center for Regenerative Medicine. S Yamada, A Behfar and A Terzic are inventors on regenerative sciences related intellectual property disclosed to Mayo Clinic. Previously, Mayo Clinic has administered research grants from Celyad. Mayo Clinic, A Behfar and A Terzic have interests in Rion LLC. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Funding Information: The authors are supported by the National Institutes of Health (R01 HL134664), Regenerative Medicine Minnesota, Marriott Family Foundation, Van Cleve Cardiac Regenerative Medicine Program, Michael S and Mary Sue Shannon Family, Center for Regenerative Publisher Copyright: {\textcopyright} 2021 ",
year = "2021",
month = jun,
doi = "10.2217/bmm-2020-0683",
language = "English (US)",
volume = "15",
pages = "775--783",
journal = "Biomarkers in Medicine",
issn = "1752-0363",
publisher = "Future Medicine Ltd.",
number = "10",
}