Screening for Lung Cancer

David E. Midthun

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


The National Lung Screening Study has demonstrated that screening with low-dose spiral computed tomography results in fewer deaths from lung cancer compared with screening with chest radiography (CXR). Previous trials of screening with CXR and sputum cytology failed to exhibit fewer deaths compared with no screening intervention. Early computed tomography (CT) studies showed promise for CT to be a more sensitive test, yet were unable to demonstrate sufficient evidence of efficacy. This review examines the problem of early lung cancer detection, the issues presented by screening, and results of past and recent studies of lung cancer screening.

Original languageEnglish (US)
Pages (from-to)659-668
Number of pages10
JournalClinics in Chest Medicine
Issue number4
StatePublished - Dec 2011


  • Computed tomography screening
  • Mortality reduction
  • Nodule evaluation
  • Randomized trials
  • Screen bias

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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