Screening for celiac disease in the general population and in high-risk groups

Jonas F. Ludvigsson, Timothy R. Card, Katri Kaukinen, Julio Bai, Fabiana Zingone, David S. Sanders, Joseph A. Murray

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations


Background: Celiac disease (CD) occurs in approximately 1% of the Western population. It is a lifelong disorder that is associated with impaired quality of life (QOL) and an excessive risk of comorbidity and death. Objectives: To review the literature on screening for CD in relation to the current World Health Organization (WHO) criteria for mass screening. Methods: We performed a PubMed search to identify indexed papers on CD screening with a publication date from 1900 until 1 June 2014. When we deemed an abstract relevant, we read the corresponding paper in detail. Results: CD fulfills several WHO criteria for mass screening (high prevalence, available treatment and difficult clinical detection), but it has not yet been established that treatment of asymptomatic CD may reduce the excessive risk of severe complications, leading to higher QOL nor that it is cost-effective. Conclusions: Current evidence is not sufficient to support mass screening for CD, but active case-finding may be appropriate, as we recognize that most patients with CD will still be missed by this strategy. Although proof of benefit is still lacking, screening for CD may be appropriate in high-risk groups.

Original languageEnglish (US)
Pages (from-to)106-120
Number of pages15
JournalUnited European Gastroenterology Journal
Issue number2
StatePublished - Apr 2015


  • Celiac disease
  • Gluten
  • Gluten-free diet
  • Prevention
  • Quality of life
  • Review
  • Risk
  • Screening
  • World health organization

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology


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