Scrambler Therapy for the management of chronic pain

Neil Majithia, Thomas J. Smith, Patrick J. Coyne, Salahadin Abdi, Deirdre R. Pachman, Daniel Lachance, Randy Shelerud, Andrea Cheville, Jeffrey R. Basford, David Farley, Carrie O’Neill, Kathryn J. Ruddy, Frank Sparadeo, Andreas Beutler, Charles L. Loprinzi

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Purpose: Chronic pain is a widespread and debilitating condition, encountered by physicians in a variety of practice settings. Although many pharmacologic and behavioral strategies exist for the management of this condition, treatment is often unsatisfactory. Scrambler Therapy is a novel, non-invasive pain modifying technique that utilizes trans-cutaneous electrical stimulation of pain fibers with the intent of re-organizing maladaptive signaling pathways. This review was conducted to further evaluate what is known regarding the mechanisms and mechanics of Scrambler Therapy and to investigate the preliminary data pertaining to the efficacy of this treatment modality. Methods: The PubMed/Medline, SCOPUS, EMBASE, and Google Scholar databases were searched for all articles published on Scrambler Therapy prior to November 2015. All case studies and clinical trials were evaluated and reported in a descriptive manner. Results: To date, 20 reports, of varying scientific quality, have been published regarding this device; all but one small study, published only as an abstract, provided results that appear positive. Conclusion: The positive findings from preliminary studies with Scrambler Therapy support that this device provides benefit for patients with refractory pain syndromes. Larger, randomized studies are required to further evaluate the efficacy of this approach.

Original languageEnglish (US)
Pages (from-to)2807-2814
Number of pages8
JournalSupportive Care in Cancer
Issue number6
StatePublished - Jun 1 2016


  • Chemotherapy-induced peripheral neuropathy
  • Chronic pain
  • Pain
  • Scrambler Therapy

ASJC Scopus subject areas

  • Oncology


Dive into the research topics of 'Scrambler Therapy for the management of chronic pain'. Together they form a unique fingerprint.

Cite this