Scleroderma Induced by Pembrolizumab: A Case Series

Naiara S. Barbosa, David A. Wetter, Carilyn N. Wieland, Niraj K. Shenoy, Svetomir N. Markovic, Uma Thanarajasingam

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Immune checkpoint inhibitors are approved for select cancer treatment and have shown survival benefit in patients with advanced melanoma. Adverse events, including immune-related adverse events, are common and potentially life-threatening. We describe cases of 2 patients with scleroderma (patient 1 had diffuse scleroderma, and patient 2 had limited scleroderma) that developed while they were receiving pembrolizumab therapy for metastatic melanoma. Prompt recognition and treatment of immune-related adverse events may improve tolerance to immune checkpoint inhibitors and contribute to an understanding of the manifesting autoimmune disease.

Original languageEnglish (US)
Pages (from-to)1158-1163
Number of pages6
JournalMayo Clinic proceedings
Issue number7
StatePublished - Jul 2017

ASJC Scopus subject areas

  • General Medicine


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