Science signaling podcast for 2 August 2016: Patient. specific protein complexes

Adam G. Schrum, Steven C. Neier, Annalisa M. VanHook

Research output: Contribution to journalArticlepeer-review


This Podcast features an interview with Adam Schrum and Steven Neier, authors of a Research Article that appears in the 2 August 2016 issue of Science Signaling, about a method for identifying protein.protein interactions in patient tissue samples. The authors used this method to compare signaling complexes downstream of the T cell receptor in T cells from healthy skin with those in T cells from the skin of patients with the autoimmune disease alopecia areata. The study revealed differences in the relative abundance of some protein complexes between T cells from the control and patient groups. This technique could be adapted for use as a diagnostic tool to stratify patients by molecular phenotype and predict the therapeutic strategy that is likely to work best for each patient.

Original languageEnglish (US)
Article numberpc17
JournalScience Signaling
Issue number439
StatePublished - Aug 2 2016


  • Alopecia areata
  • Autoimmune disease
  • Baldness
  • Diagnostic tool
  • GADS
  • GRB2
  • LAT
  • Linker of activated T cells
  • Personal medicine
  • Protein. protein complex
  • Science Signaling
  • T cell receptor
  • TCR signalosome

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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