Schwarz meets Schwann: design and fabrication of biomorphic tissue engineering scaffolds.

Srinivasan Rajagopalan, Richard A. Robb

Research output: Chapter in Book/Report/Conference proceedingChapter


Tissue engineering is a discipline at the leading edge of the field of computer assisted intervention. This multidisciplinary engineering science is based on the notion of design and fabrication of scaffolds- porous, three-dimensional "trellis-like" biomimetic structures that, on implantation, provide a viable environment to recuperate and regenerate damaged cells. Existing CAD-based approaches produce porous labyrinths with contra-naturam straight edges. The biomorphic geometry that mimics the secundam-naturam substrate would be one that is continuous through all space, partitioned into two not-necessarily-equal sub-spaces by a non-intersecting, two-sided surface. Minimal surfaces are ideal to describe such a space. We present results on the premier attempt in computer controlled fabrication and mechanical characterization of Triply Periodic Minimal Surfaces [TPMS]. This initiative is a significant step to link Schwann's 1838 cell theory with Schwarz's discovery of TPMS in 1865 to fabricate the previously elusive optimal biomorphic tissue analogs.

Original languageEnglish (US)
Title of host publicationMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Number of pages8
EditionPt 1
StatePublished - 2005


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