Say when: Reversible control of gene expression in the mouse by lac

Heidi Scrable

doi:10.1016/S1084-9521(02)00017-4

Say when: Reversible control of gene expression in the mouse by lac

Heidi Scrable

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

In bacteria, coordinate expression of genes involved in lactose metabolism is regulated by the lac repressor and its DNA binding sequence, the lac operator. The lac operator-repressor complex can also be used to regulate gene expression in the laboratory mouse. In this review, I discuss the current state of murine trans-operons, and suggest ways this lac-based system might be used to build more advanced models of human diseases in the mouse.

Original language	English (US)
Pages (from-to)	109-119
Number of pages	11
Journal	Seminars in Cell and Developmental Biology
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/S1084-9521(02)00017-4
State	Published - 2002

Keywords

Animal model
Conditional
E. coli
Lac operator
Lac operon
Lac repressor
Transgenic

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1016/S1084-9521(02)00017-4

Cite this

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title = "Say when: Reversible control of gene expression in the mouse by lac",

abstract = "In bacteria, coordinate expression of genes involved in lactose metabolism is regulated by the lac repressor and its DNA binding sequence, the lac operator. The lac operator-repressor complex can also be used to regulate gene expression in the laboratory mouse. In this review, I discuss the current state of murine trans-operons, and suggest ways this lac-based system might be used to build more advanced models of human diseases in the mouse.",

keywords = "Animal model, Conditional, E. coli, Lac operator, Lac operon, Lac repressor, Transgenic",

author = "Heidi Scrable",

note = "Funding Information: I thank the members of my laboratory for many interesting and fruitful discussions. In addition, I thank my graduate students Carolyn Cronin and Amy Ryan for material used in Figures 2 and 4, respectively. I am grateful to Peter Stambrook for being a constant source of good ideas and good will. Work in my laboratory is supported by grants from the National Institutes of Health (RR11102 and AG20915) and the Hereditary Disease Foundation. ",

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T2 - Reversible control of gene expression in the mouse by lac

AU - Scrable, Heidi

N1 - Funding Information: I thank the members of my laboratory for many interesting and fruitful discussions. In addition, I thank my graduate students Carolyn Cronin and Amy Ryan for material used in Figures 2 and 4, respectively. I am grateful to Peter Stambrook for being a constant source of good ideas and good will. Work in my laboratory is supported by grants from the National Institutes of Health (RR11102 and AG20915) and the Hereditary Disease Foundation.

PY - 2002

Y1 - 2002

N2 - In bacteria, coordinate expression of genes involved in lactose metabolism is regulated by the lac repressor and its DNA binding sequence, the lac operator. The lac operator-repressor complex can also be used to regulate gene expression in the laboratory mouse. In this review, I discuss the current state of murine trans-operons, and suggest ways this lac-based system might be used to build more advanced models of human diseases in the mouse.

AB - In bacteria, coordinate expression of genes involved in lactose metabolism is regulated by the lac repressor and its DNA binding sequence, the lac operator. The lac operator-repressor complex can also be used to regulate gene expression in the laboratory mouse. In this review, I discuss the current state of murine trans-operons, and suggest ways this lac-based system might be used to build more advanced models of human diseases in the mouse.

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KW - Lac operon

KW - Lac repressor

KW - Transgenic

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Say when: Reversible control of gene expression in the mouse by lac

Abstract

Keywords

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