SARS-CoV-2 and Pregnancy: A Review of the Facts

Ricardo Mamber Czeresnia, Ayssa Teles Abrao Trad, Ingrid Schwach Werneck Britto, Romulo Negrini, Marcelo Luís Nomura, Pedro Pires, Fabricio Da Silva Costa, Roseli Mieko Yamamoto Nomura, Rodrigo Ruano

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Objective The present comprehensive review aims to show the full extent of what is known to date and provide a more thorough view on the effects of SARS-CoV2 in pregnancy. Methods Between March 29 and May, 2020, the words COVID-19, SARS-CoV2, COVID-19 and pregnancy, SARS-CoV2 and pregnancy, and SARS and pregnancy were searched in the PubMed and Google Scholar databases; the guidelines from well-known societies and institutions (Royal College of Obstetricians and Gynaecologists [RCOG], American College of Obstetricians and Gynecologists [ACOG], International Society of Ultrasound in Obstetrics & Gynecology [ISUOG], Centers for Disease Control and Prevention [CDC], International Federation of Gynecology and Obstetrics [FIGO]) were also included. Conclusion The COVID-19 outbreak resulted in a pandemic with > 3.3 million cases and 230 thousand deaths until May 2 nd. It is caused by the SARS-CoV2 virus and may lead to severe pulmonary infection and multi-organ failure. Past experiences show that unique characteristics in pregnancy make pregnant women more susceptible to complications from viral infections. Yet, this has not been reported with this new virus. There are risk factors that seem to increase morbidity in pregnancy, such as obesity (body mass index [BMI] > 35), asthma and cardiovascular disease. Current reports describe an increased rate of preterm birth and C-section. Vertical transmission is still a possibility, due to a few reported cases of neonatal positive real-time polymerase chain reaction (RT-PCR) in nasal swab, amniotic fluid, and positive immunoglobulin M (IgM) in neonatal blood. Treatments must be weighed in with caution due to the lack of quality trials that prove their effectiveness and safety during pregnancy. Medical staff must use personal protective equipment in handling SARS-CoV2 suspected or positive patients and be alert for respiratory decompensations.

Original languageEnglish (US)
Pages (from-to)562-568
Number of pages7
JournalRevista Brasileira de Ginecologia e Obstetricia
Issue number9
StatePublished - Sep 1 2020


  • SARS-CoV-2
  • guidelines
  • physiology
  • pregnancy
  • treatment

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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