SALTIRE-RAAVE: Targeting calcific aortic valve disease LDL-density-radius theory

Nalini M. Rajamannan, Anders M. Greve, Luis M. Moura, Patricia Best, Kristian Wachtell

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


SALTIRE and RAAVE were the first two studies to evaluate the use of statin therapy for impeding calcific aortic valve disease (CAVD). This review presents the findings of low-density lipoprotein (LDL)-density-radius theory as tested using the combined results from the SALTIRE and RAAVE studies. Patients who received statin therapy had a greater degree of LDL cholesterol lowering, seen as the % change in LDL (47 vs 2%, p ≥ 0.012), which in itself was significantly associated with a lesser change in aortic valve area (AVA; p < 0.001 and R2 ≥ 0.27). The percent change in the AVA for the treated patients was 5% and 15% for the nontreated patients (p ≥ 0.579 and R2 ≥ 0.03). In summary, these published findings suggest that when applying the LDL-density-radius theory, which combines the cellular biology and the hemodynamics as defined by the continuity equation for AVA, there may be a role for lipid-lowering therapy in contemporary patients with calcific aortic valve disease (CAVD).

Original languageEnglish (US)
Pages (from-to)355-367
Number of pages13
JournalExpert Review of Cardiovascular Therapy
Issue number4
StatePublished - Apr 1 2015


  • aortic valve stenosis
  • atherosclerosis
  • calcification
  • clinical trials
  • hemodynamics
  • statins

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine


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