Salmeterol and airway response to allergen

Donald W. Cockcroft, Veronica A. Swystun, Rajesh Bhagat, Sanjay Kalra

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background: Regular treatment with inhaled salbutamol (seven to 14 days) increases airway responsiveness to allergen. OBJECTIVE: To assess the effect of salmeterol 50 μg twice daily for six days on the early asthmatic response to allergen (PC15). DESIGN: Double-blind, randomized, crossover trial comparing salmeterol with placebo (twice daily over six days) with one week or more washout. Forced expiratory volume in 1 s (FEV1) and allergen PC15 were measured 36 h after each treatment was discontinued. Setting: Tertiary care out-patient bronchoprovocation laboratory. Subjects: Fourteen atopic asthmatics well controlled with (n = 5) or without (n = 9) inhaled corticosteroids. Subjects did not use inhaled beta-agonists for at least two weeks before and during the trial. Results: FEV1 was slightly but significantly lower 36 h after the last dose of salmeterol versus placebo (3.28 ± 0.83 versus 3.40 ± 0.88 L, P = 0.032). Airway responsiveness to allergen increased by about half a doubling concentration (log10 PC15 2.71 ± 0.61 versus 2.85 ± 0.61, P = 0.047). Conclusion: A six-day treatment course of salmeterol 50 μg twice daily resulted in a slight decline in FEV1 and a modest increase in airway response to allergen at 36 h.

Original languageEnglish (US)
Pages (from-to)37-40
Number of pages4
JournalCanadian Respiratory Journal
Issue number1
StatePublished - 1997


  • Airway response
  • Allergen
  • Asthma
  • Inhaled corticosteroids
  • Salmeterol

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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