Safety factor for neuromuscular transmission at type-identified diaphragm fibers

Leonid G. Ermilov, Carlos B. Mantilla, Katharine L. Rowley, Gary C. Sieck

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


The safety factor (SF) for neuromuscular transmission varies across limb muscles of different fiber-type composition. Using intracellular recordings in rat diaphragm fibers, we found that SF varies across muscle fiber types (even within a single muscle), being larger for type IIx or IIb fibers than for type I or IIa fibers. Fiber-type differences in activation history or mechanical load may contribute to differences in SF and are important determinants of neuromuscular plasticity.

Original languageEnglish (US)
Pages (from-to)800-803
Number of pages4
JournalMuscle and Nerve
Issue number6
StatePublished - Jun 2007


  • Motor unit
  • Phrenic motoneurons
  • Plasticity
  • Synaptic efficacy
  • Ventilation

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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