Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats

Michael Guarnieri; Cory Brayton; Louis Detolla; Nadine Forbes-Mcbean; Rachel Sarabia-Estrada; Patricia Zadnik

doi:10.1038/laban.152

Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats

Michael Guarnieri, Cory Brayton, Louis Detolla, Nadine Forbes-Mcbean, Rachel Sarabia-Estrada, Patricia Zadnik

Neurosurgery

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

Buprenorphine is a long-acting opiate with a high therapeutic index. The authors review the pharmacology, toxicity, analgesic effects and delivery of buprenorphine for use in laboratory mice and rats. Buprenorphine-based analgesic therapy has a substantial record of safety, and there is growing evidence of its effectiveness for treating post-operative pain. Nonetheless, more research is needed to determine optimal delivery systems and analgesic regimens for pain therapy in laboratory animals.

Original language	English (US)
Pages (from-to)	337-343
Number of pages	7
Journal	Lab Animal
Volume	41
Issue number	11
DOIs	https://doi.org/10.1038/laban.152
State	Published - Nov 2012

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

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10.1038/laban.152

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title = "Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats",

abstract = "Buprenorphine is a long-acting opiate with a high therapeutic index. The authors review the pharmacology, toxicity, analgesic effects and delivery of buprenorphine for use in laboratory mice and rats. Buprenorphine-based analgesic therapy has a substantial record of safety, and there is growing evidence of its effectiveness for treating post-operative pain. Nonetheless, more research is needed to determine optimal delivery systems and analgesic regimens for pain therapy in laboratory animals.",

author = "Michael Guarnieri and Cory Brayton and Louis Detolla and Nadine Forbes-Mcbean and Rachel Sarabia-Estrada and Patricia Zadnik",

note = "Funding Information: The authors declare competing financial interests. Funding to support this work was obtained from the biotechnology and economic development programs of maryland Technology Development Corporation (TeDCo) and maryland Industrial Partnerships (mIPS) and from bamvet Laboratories, Inc. P.Z. is a paid consultant for bamvet and is supported by a Johns Hopkins medical research Fellowship. m.G. holds a significant financial interest in bamvet.",

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AU - Brayton, Cory

AU - Detolla, Louis

AU - Forbes-Mcbean, Nadine

AU - Sarabia-Estrada, Rachel

AU - Zadnik, Patricia

N1 - Funding Information: The authors declare competing financial interests. Funding to support this work was obtained from the biotechnology and economic development programs of maryland Technology Development Corporation (TeDCo) and maryland Industrial Partnerships (mIPS) and from bamvet Laboratories, Inc. P.Z. is a paid consultant for bamvet and is supported by a Johns Hopkins medical research Fellowship. m.G. holds a significant financial interest in bamvet.

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Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats

Abstract

ASJC Scopus subject areas

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