Role of the Intestinal Microbiome in Cholestatic Liver Disease

Nicholas F. Larusso, James H. Tabibian, Steven P. O'Hara

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Hepatobiliary health and disease is influenced by multiple factors including genetics, epigenetics, and the environment. Recently, multiple lines of evidence suggest that the microbiome also plays a central role in the initiation and/or progression of several liver diseases. Our current understanding of the dynamic interplay between microbes, microbial products and liver health and pathophysiology is incomplete. However, exciting insights are continually being made that support both a central role of the microbiome and a need for further interrogation of the microbes or microbe-associated molecules involved in the initiation and progression of select liver diseases.

Original languageEnglish (US)
Pages (from-to)166-168
Number of pages3
JournalDigestive Diseases
Issue number3
StatePublished - Mar 1 2017


  • Liver diseases
  • Microbiota
  • Sclerosing cholangitis
  • Senescence

ASJC Scopus subject areas

  • Gastroenterology


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