Role of PAPP-A in aging and age-related disease

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18 Scopus citations


As suggested by its name, pregnancy-associated plasma protein-A (PAPP-A) plays an important role in pregnancy and fetal development (Brizot et al., 1996; Lin et al., 1974; Smith et al., 2002). On the opposite end of life's spectrum, recent studies using genetically-engineered mice indicate a newly recognized role for PAPP-A in aging and in the development of age-related disease. These latter studies will be reviewed in this article.

Original languageEnglish (US)
Pages (from-to)612-613
Number of pages2
JournalExperimental Gerontology
Issue number7
StatePublished - Jul 2013


  • Aging
  • Atherosclerosis
  • Cancer
  • Insulin-like growth factors
  • Pregnancy-associated plasma protein-A

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology


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