TY - JOUR
T1 - Role of Dobutamine-Atropine Stress Echocardiography in Prognostic Evaluation of 300 Women
AU - Cordovil, Adriana
AU - Mathias, Wilson
AU - Andrade, José Lázaro
AU - Campos Filho, Orlando
AU - Moisés, Valdir Ambrósio
AU - Gil, Manoel Adán
AU - Machado, Cristiano Vieira
AU - Arruda, Adelaide Maria
AU - Paiva, Marcelo Goulart
AU - Carvalho, Antonio C.
AU - De Paola, Angelo A.V.
PY - 2004/2
Y1 - 2004/2
N2 - Background: Dobutamine-atropine stress echocardiography (DASE) is a safe and accurate method to diagnose coronary artery disease (CAD), and can identify individuals at high risk for cardiac events such as myocardial infarction and cardiac-related death. The literature is limited regarding the prognostic value of DASE in women. Objective: The objective was to determine the prognostic value of DASE in 300 women with known or suspected CAD. Results: The 300 women underwent DASE and were followed up for 65 months (mean: 27 months). Ninety-five women had positive tests and 205 had negative tests. We demonstrated that women with negative tests had a 94% hard-event-free survival rate at follow-up (myocardial infarction and death), and in those with positive tests the event-free survival rate was 27% (P = 0.0003). The difference between women with positive and negative tests was also significant when minor events and total events were considered. Women with positive tests had 16.7 times more chance of having events than women with negative tests. Furthermore, women with positive tests but without cardiac events at follow-up (mean of peak WMSI - rest WMSI = 0.24 ± 0.16) had less ischemic myocardium than women with positive tests and cardiac events at follow-up (mean of peak WMSI - rest WMSI = 0.34 ± 0.26)(P < 0.04). Conclusion: Dobutamine-atropine stress echocardiography has good prognostic value for cardiac events in women. Women with negative tests have low probability for follow-up infarction or death. Women with positive tests and higher severity of induced ischemia have the highest incidence of cardiac events.
AB - Background: Dobutamine-atropine stress echocardiography (DASE) is a safe and accurate method to diagnose coronary artery disease (CAD), and can identify individuals at high risk for cardiac events such as myocardial infarction and cardiac-related death. The literature is limited regarding the prognostic value of DASE in women. Objective: The objective was to determine the prognostic value of DASE in 300 women with known or suspected CAD. Results: The 300 women underwent DASE and were followed up for 65 months (mean: 27 months). Ninety-five women had positive tests and 205 had negative tests. We demonstrated that women with negative tests had a 94% hard-event-free survival rate at follow-up (myocardial infarction and death), and in those with positive tests the event-free survival rate was 27% (P = 0.0003). The difference between women with positive and negative tests was also significant when minor events and total events were considered. Women with positive tests had 16.7 times more chance of having events than women with negative tests. Furthermore, women with positive tests but without cardiac events at follow-up (mean of peak WMSI - rest WMSI = 0.24 ± 0.16) had less ischemic myocardium than women with positive tests and cardiac events at follow-up (mean of peak WMSI - rest WMSI = 0.34 ± 0.26)(P < 0.04). Conclusion: Dobutamine-atropine stress echocardiography has good prognostic value for cardiac events in women. Women with negative tests have low probability for follow-up infarction or death. Women with positive tests and higher severity of induced ischemia have the highest incidence of cardiac events.
KW - Dobutamine
KW - Echocardiography
KW - Prognostic
KW - Women
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U2 - 10.1111/j.0742-2822.2004.03054.x
DO - 10.1111/j.0742-2822.2004.03054.x
M3 - Article
C2 - 14961788
AN - SCOPUS:10744224691
SN - 0742-2822
VL - 21
SP - 113
EP - 118
JO - Echocardiography
JF - Echocardiography
IS - 2
ER -