Role of Dobutamine-Atropine Stress Echocardiography in Prognostic Evaluation of 300 Women

Adriana Cordovil, Wilson Mathias, José Lázaro Andrade, Orlando Campos Filho, Valdir Ambrósio Moisés, Manoel Adán Gil, Cristiano Vieira Machado, Adelaide Maria Arruda, Marcelo Goulart Paiva, Antonio C. Carvalho, Angelo A.V. De Paola

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Dobutamine-atropine stress echocardiography (DASE) is a safe and accurate method to diagnose coronary artery disease (CAD), and can identify individuals at high risk for cardiac events such as myocardial infarction and cardiac-related death. The literature is limited regarding the prognostic value of DASE in women. Objective: The objective was to determine the prognostic value of DASE in 300 women with known or suspected CAD. Results: The 300 women underwent DASE and were followed up for 65 months (mean: 27 months). Ninety-five women had positive tests and 205 had negative tests. We demonstrated that women with negative tests had a 94% hard-event-free survival rate at follow-up (myocardial infarction and death), and in those with positive tests the event-free survival rate was 27% (P = 0.0003). The difference between women with positive and negative tests was also significant when minor events and total events were considered. Women with positive tests had 16.7 times more chance of having events than women with negative tests. Furthermore, women with positive tests but without cardiac events at follow-up (mean of peak WMSI - rest WMSI = 0.24 ± 0.16) had less ischemic myocardium than women with positive tests and cardiac events at follow-up (mean of peak WMSI - rest WMSI = 0.34 ± 0.26)(P < 0.04). Conclusion: Dobutamine-atropine stress echocardiography has good prognostic value for cardiac events in women. Women with negative tests have low probability for follow-up infarction or death. Women with positive tests and higher severity of induced ischemia have the highest incidence of cardiac events.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
Issue number2
StatePublished - Feb 2004


  • Dobutamine
  • Echocardiography
  • Prognostic
  • Women

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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