Caveolae are flask-shaped invaginations of the plasma membrane that are rich in lipids and serve as microdomains to facilitate interactions between proteins at the membrane as well as intracellular components, thus modulating signal transduction, protein and lipid transport, and other processes. Constituent caveolar proteins such as caveolins and cavins also have scaffolding domains that anchor and regulate protein function. There is now evidence that caveolae and their constituent proteins are present in airway smooth muscle in a variety of species. Caveolae in airway cells contain or interact with molecules such as receptors, ion channels, and regulatory proteins that are key to the roles of airway epithelium and smooth muscle in regulating airway structure and function. Furthermore, caveolar protein expression and regulation appear to be important in mediating and modulating the effects of inflammation on the airway, thereby contributing to the pathophysiology of diseases such as asthma.
|Title of host publication
|Calcium Signaling In Airway Smooth Muscle Cells
|Springer International Publishing
|Number of pages
|Published - Nov 1 2014
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology