Role of cardiac MRI and nuclear imaging in cardiac resynchronization therapy

Niti R. Aggarwal, Matthew W. Martinez, Bernard J. Gersh, Panithaya Chareonthaitawee

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Cardiac resynchronization has emerged as a highly effective therapy for heart failure. However, up to 40% of patients do not benefit from this treatment. In this Review, we discuss the potential role of MRI and nuclear molecular imaging in providing additional insights into the response to cardiac resynchronization therapy. Variables with potential prognostic and therapeutic values include the evaluation of cardiac dyssynchrony, scar, cardiac sympathetic function, myocardial blood flow, myocardial glucose and oxidative metabolism. Other molecular targets to characterize apoptosis, fatty acid metabolism, angiogenesis and angiotensin-converting enzyme activity will also be described. The potential use of these techniques in identifying and measuring responses to cardiac resynchronization therapy and future areas of research will be explored.

Original languageEnglish (US)
Pages (from-to)759-770
Number of pages12
JournalNature Reviews Cardiology
Issue number12
StatePublished - Dec 4 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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